Job description
Job Description
General Summary:
We are seeking a Proteomics Biologist to join the Chemical Biology group in Vertex Pharmaceuticals as Research Scientist.
The ideal candidate is a motivated, detail orientated, life-long learner with strong technical expertise in molecular biology, proteomics, and mass spectrometry. The successful candidate will have the technical and problem-solving skills to create biological tools and conduct proteomic experiments to address challenging questions in exploratory drug discovery. As a member of a dynamic, multi-disciplinary group, the individual will have the opportunity to participate across a broad range of exciting scientific endeavors across several disease areas.
The ideal candidate is a motivated, detail orientated, life-long learner with strong technical expertise in molecular biology, proteomics, and mass spectrometry. The successful candidate will have the technical and problem-solving skills to create biological tools and conduct proteomic experiments to address challenging questions in exploratory drug discovery. As a member of a dynamic, multi-disciplinary group, the individual will have the opportunity to participate across a broad range of exciting scientific endeavors across several disease areas.
Key Duties and Responsibilities:
- Design and execution of studies interrogating protein-protein interactions, chemo-proteomics, signaling and homeostasis at the proteome-wide scale.
- Generate bespoke assays for classically difficult to measure proteins to enable target discovery, hit validation, biomarker and mechanism of action studies.
- Prepare and process samples for complex protein workflows, including enrichment, fractionation, and digestion.
- Generate and maintain cell lines with modified genes of interest, including tags, overexpression, and knockouts.
- Execute, maintain, and develop proteomic workflows.
- Work in a multi-disciplinary matrix environment, collaborating on shared scientific questions, communicating ideas, plans and results.
- Organize, record, and report results according to data integrity guidelines.
Education and Experience:
- Ph.D. in life sciences with 0-3 years or MS with 3+ years or BS with 6+ years of relevant hands-on experience in protein peptide mass spectrometry and molecular biology.
- Experience with target centric proteomics and associated tools for deconvoluting PPIs, mechanism of action, chemoproteomics, and systems biology questions.
- Well-rounded molecular biology toolkit including: CRISPR, transient transfection, generating stable cell lines, protein tagging, Western blotting, etc.
- Hands-on liquid chromatography and mass spectrometry instrumentation experience, including method design, troubleshooting and maintenance.
- Experience with quantitative analysis of mass spectrometry software such as Skyline, Proteome Discoverer, Maxquant and MsFragger.
- Self-driven ability to organize resources and data, manage time and priorities.
- The ability to communicate ideas and updates clearly and concisely across a variety of audience levels.
- Articulate in cell and molecular biology, analytical quantification, and drug discovery concepts.
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Company Information
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com.
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